Rust disease is usually more on the carapace. But this could spread to the body area if not treated.
While it's still isolated at the tail, it is easier to treat with antibacterial meds.
If this was my shrimp, I'd catch it and put a drop of Melafix (or some other similar antibac/antibiotic) directly on the tail. Leave it for a minute before putting the shrimp back into the tank.
When you think of potential predators, you might be thinking of a fish that can outright swallow a whole shrimp. Fish don't predate on shrimp like that necessarily. When the fish are large enough, but still too small to swallow a shrimp whole, they take bites out of the shrimp. A Bolivian and Serpae are definitely going to be enough to take bites out of a shrimp, even one the size of an Amano.
Your shrimp are probably hiding for that reason and only venturing out more because they are hungry.
There are other reasons a shrimp hides, and that can be because of unsuitable water parameters. If you can test the water and share it here, we can advise if that is a problem.